7 Supplement

Abstract

Several new types of human papilloma viruses and one new type of bovine papilloma virus have been identified recently. All known human and bovine viruses are listed in Table S7.1.

Law et al. (1979), Howley et al. (1980), and Heilman et al. (1980) have detected conserved polynucleotide sequences among the genomes of papilloma viruses. Under conditions of low stringency, stable hybrid DNA was formed between specific regions of the respective genomes of BPV-1, BPV-2, HPV-1, HPV-2, HPV-4, and Shope papilloma virus. These conserved sequences have also been detected in the genomes of canine oral papillomatosis virus (Pfister and Meszaros 1980) and the human papilloma virus types HPV-6 and HPV-8 (Gissmann et al., in prep.). Apparently the genomes of most papilloma virus types share a common region. The biological function of these common sequences has not yet been identified.

Considerable effort has been spent analyzing the state of papilloma virus DNA in non-virus-producing papillomas, carcinomas, or tissue-culture lines. Stevens and Wettstein (1979) reported the presence of 10 to 100 copies of viral DNA in carcinomas induced by the Shope papilloma virus. They also showed (Wettstein and Stevens 1980) that at least some unintegrated supercoiled viral genomes were present in carcinomas and metastatic tumors induced by this virus. Amtmann et al. (1980) and Lancaster (1981) found that BPV type-1 and type-2 DNAs extracted from equine sarcoids, equine and bovine tumor cell lines, and a line of mouse cells transformed by BVP-1 coelectrophoresed with supercoiled virion DNA.

Orth et al. (1980) also obtained...